This is such an important paper in the field of urology, substantiating the role of radical prostatectomy in patients with early prostate cancer.
When compared to watchful waiting, prostatectomy was clearly shown to reduce disease-specific mortality, overall mortality, and the risks of metastatic and local progression.

Read the full article here:

Bill-Axelson A, Holmberg L, Ruutu M, et al. Radical prostatectomy versus watchful waiting in early prostate cancer. N ENgl J Med 2005; 352:1977-1984